Tamoxifen citrate/Tamoxifen/abbreviation TCT

Basic information:

Product Name: Tamoxifen citrate 

Synonyms: 1-p-beta-dimethylaminoethoxyphenyl-trans-1,2-diphenylbut-1-ene citrate;(z)-2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethanamine,citrate(1:;(z)-2-(para-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethylethylaminecitrate(;2-(4-(1,2-diphenyl-1-butenyl)phenoxy)-n,n-dimethyl-ethanamin(z)-ethanamin2-hydrox;ici46,474;kessar;noltam;tamofen 

CAS: 54965-24-1 

MF: C32H37NO8 

MW: 563.64 

EINECS: 259-415-2 

Product Categories: Active Pharmaceutical Ingredients;Antitumors for Research and Experimental Use;Biochemistry;API's;Intracellular receptor;Steroid and Hormone;API;SOLTAMOX;Inhibitors 

Mol File: 54965-24-1.mol 

Chemical Properties:

MP 140-144 °C  

storage temp.  2-8°C

Water Solubility  slightly soluble 

Merck  9048 

Appearance white to off-white powder

Safety Information:

Hazard Codes  T,Xi 

Risk Statements  45-60-61-22-64-36/37/38 

Safety Statements  53-36/37/39-45-36-26 

WGK Germany  3

RTECS  KH2387000

HazardClass  IRRITANT 

Overview:

Tamoxifen citrate(Tamoxifen, abbreviation TCT ), is an estrogen competitive antagonist and non-steroidal anti-estrogen drug. It can compete with estrogen (estradiol) to combine with estrogen receptor of breast cancer cells, inhibiting the effect of estrogen on cancer cells, and stunting growth and development of tumor cells to show anticancer effects. Clinically Tamoxifen citrate is commonly used to treat various types of breast cancer, especially for postmenopausal breast cancer women with the positive of estrogen receptor and progesterone receptor and with low prostate-specific antigen levels.

Clinical application:

1. Treatment of breast cancer. 

2. Prevention of breast cancer.

3. Anti-tumor and anti-multidrug resistance. 

By reducing membrane negotiability and enhancing rigidity of inter-cell binding site, Tamoxifen citrate can reduce concentration and activity of cancer metastasis promoter and various activating enzymes, so as to inhibit or hinder growth and metastasis of cancer cell. In addition, it can promote cells surrounding tumor focus to secrete a negative growth factor - transforming growth factor TGF- G, inhibiting multiply indefinitely of cancer cells; inhibiting oxidative damage of DNA bases which is caused by hydrogen peroxide generated from human neutrophils. So except for breast cancer, it is good for treatment and prevention of other malignant neoplasms, and is used for treatment of brain tumors, liver cancer, prostate cancer, etc. In addition, Tamoxifen citrate can reduce release effect of membrane P170 glycoprotein through reducing membrane negotiability, improving intracellular effective concentration of cytotoxic drug and reducing drug resistance.

4. Heart protection.

Usage And Synthesis:

Usage anti-estrogen, protein kinase C inhibitor, beneficial cardiovascular effects, bone cancer treatment, induces DNA adduct formation 

Safe and discreet package

1).All products will have been strictly Quality Checked in house before packing. 2).All products will be well packed before shipping. 3)Parcel can be sent out in 24 hours after payment. Tracking number available 4)Secure and discreet shipment. Various transportation methods for your choice. 5)Customs pass rate ≥99% 6) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

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