Griseofulvin

Basic information:

Product Name: (+)-Griseofulvin 

Synonyms: (+)-GRISEOFULVIN;GRISEOFULVIN;[2S-TRANS]-7-CHLORO-2,4,6-TRIMETHOXY-6'-METHYLSPIRO[BENZOFURAN-2(3H), 1'(2)-CYCLOHEXANE]-3,4'-DIONE;(2S)-TRANS-7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYLSPIRO(BENZOFURAN-2[3H],1'-[2]CYCLOHEXENE)-3,4'-DIONE;7-CHLORO-2',4,6-TRIMETHOXY-6'-METHYL-, (1'S-TRANS)-SPIRO(BENZOFURAN-2(3H),1'-(2)CYCLOHEXENE)-3,4'-DIONE;(+)-griseofulvi;(2s-trans)-7-chloro-2’,4,6-trimethoxy-6’-methylspiro[benzofuran-2(3h),1’-[2]cy;(2s-trans)-xy-6’-methyl 

CAS: 126-07-8 

MF: C17H17ClO6 

MW: 352.77 

EINECS: 204-767-4 

Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Antifungal;Aromatics;Chiral Reagents;VERELAN;Inhibitors 

Mol File: 126-07-8.mol 

Chemical Properties:

MP  218-220 °C(lit.)

alpha  354 º (c=1, dimethylform) 

storage temp.  −20°C

Water Solubility  practically insoluble 

Merck  14,4549 

BRN  95226 

Griseofulvin pure product is colorless crystal, being neutral, and insoluble in water with a strong systemic property. It is stable both in vitro and in vivo of plants and is also stable to the various environment factors between pH3.0 ~ 8.8. It can be used for prevention and treatment of a variety of fungal plant diseases. The main species china applied for production of griseofulvin is Penicillium nigricans and Penicillium urticae. When grown at the medium, Penicillium nigricans is fuzzy with fresh culture being pure gray and aging culture being dark gray with its back being deep orange-red to the back orange brown. The fungi lawn of Penicillium urticae is yellowish green to pure light gray, thick and dense with the back being pale yellow to brownish; their aerial hyphae has a broom-like shape.

Safety Information :

Hazard Codes  T,Xn 

Risk Statements  60-61-40-43-45 

Safety Statements  53-22-36/37/39-45 

WGK Germany  3 

RTECS  WG9800000

Hazardous Substances Data 126-07-8(Hazardous Substances Data) 

General description:

Griseofulvin is a non-polyene class antifungal antibiotics; it can strongly inhibit the mitosis of fungal cell and interfere with the fungal DNA synthesis; it can also bind to tubulin to prevent fungal cell division. It has been applied to clinical medicine since 1958 and has currently been widely used for treating the fungal infections of the skin and the stratum corneum with strong inhibitory effects on Trichophyton rubrum and Trichophyton tonsorans, etc. Griseofulvin is not only a widely used antibiotic for clinical treatment of fungal infections of the skin and cuticle, but also applied in agriculture for prevention and treatment of fungal diseases; for example, it has a special efficacy on treating a kind of candidiasis in apple which can cause infection during pollination. 

Usage And Synthesis:

Usage :

In medicine, this product mainly has good antibacterial effect against Trichophyton, Microspores, and Epidermophyton fungi. However, it has no anti-bacterial effect on Candida, Cryptococcus, Histoplasma, Sporothrix, Blastomyces, and Coccidioides and so on. Mechanism of action of is drug is through interfering with the biosynthesis of nucleic acids of fungal and further inhibiting of its growth.

In agriculture, this product has good inhibitory effect on the Ascomycetes, Basidiomycetes, Deuteromycetes and some kinds of algae. However, it is not effective in treating oomycetes whose cell wall containing no chitin content. After spraying melons and other crops, it can be transferred into the branch, leaves and fruits through inner absorption, the absorption of water via rrot, as well as transpiration effect, and further preventing the fungal diseases; according to the study of Brandeis et al. (1946), at a concentration as low as even 10 mg/L or 1 mg/L, griseofulvin can already can make the mycelium of Bctrytis allill be stout, deformed and exhibit spiral bending, also cause: large number of abnormal branching; the development retardation of germinated spores, and loss of apical dominance; thus it has uptake therapeutic effects on a variety of plant diseases, especially powdery mildew, gray mold diseases; Griseofulvin has a more prominent antibacterial activity than the bactericidal activity. 

Indications:

1.In medicine

this product is suitable for the treatment of a variety of ringworm, including tinea capitis, tinea barbae, body tinea, jock itch, foot tinea and onychomycosis. The various kinds of tinea mentioned are caused by various fungi including Trichophyton rubrum, Trichophyton tonsorans, Trichophyton mentagrophytes, Fingers Trichophyton, etc., and Microsporon audouini, Microsporon canis, Microsporon gypseum and Epidermophyton floccosum, etc. due. This product is not suitable for treatment in mild cases, localized infection cases and cases which can be treated with topical antifungal agents. Griseofulvin is not effective in treating the infections of a various kinds of fungi such as Candida, Histoplasma, Actinomyces, Sporothrix species, Blastomyces, Coccidioides, Nocardio and Cryptococcus species as well as treating tinea versicolor.

2.In agriculture, 

This product is first introduced by Brian et al (1951) for control of plant diseases. According to previous studies, it can be used for prevention of melon (melon) vine blight, crack spread disease, watermelon blight, anthracnose, apple blossom rot, apple cold rot, apple rot, cucumber downy mildew , strawberry gray mold, gourds hanging blight, powdery mildew of roses, chrysanthemums powdery mildew, rot flower lettuce, early tomato blight, tulip fire blight and other fungal diseases. 

Adverse reactions:

1. Nervous system headache is relatively common with about 10% of patients experiencing headaches; it is a bit severe at initial stage, but will be alleviated with the continuing administration of drug; other reactions also include lethargy and fatigue. Occasional dizziness, ataxia, and peripheral neuritis may also occur. 

2. For Digestive system; a small number of patients may undergo abdominal discomfort, nausea or diarrhea, usually mild which can be tolerated by the patient.

3. Allergies can occur in about 3% of patients which suffers rash; occasionally angioneurotic edema, persistent urticaria, and exfoliative dermatitis can also occur; in very rare cases, photosensitive dermatitis can occur at a small number of patients.

4. This product can sometimes cause reduction of the number of peripheral blood leukocyte; sometime can even cause liver toxicity and proteinuria. 

Safe and discreet package

1).All products will have been strictly Quality Checked in house before packing. 2).All products will be well packed before shipping. 3)Parcel can be sent out in 24 hours after payment. Tracking number available 4)Secure and discreet shipment. Various transportation methods for your choice. 5)Customs pass rate ≥99% 6) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

Shanghai Shu Can Industrial Co.,Ltd. is one of the leading manufacturers, exporters, suppliers &amp;traders of high quality Testosterone Enanthate, Testosterone Steroids, Steroids Powder, Steroid Hormone Powder, Testosterone Enanthate Powder, Trenbolone Hormone Powders and many more. The chemical is processed in completely hygienic environment which keep it pure and safe. The gamut is known for its high stability, accurate composition, effectiveness and reliability. It is used in various pharmaceutical sectors for making tablets, capsules or other components.<br />
Our company is always committed towards quality hence never compromise on it at any cost. Our entire range of product is checked for quality at regular interval of time in our well equipped quality testing unit. Also, we have built a state-of-the-art infrastructure, which is located in the Hubei,
China. The unit is fitted with all required amenities and equipment assisting us in giving desired shape to the products. Apart, our range is offered with easy payment options so that hassle free transaction process can be conducted. In addition to this, we welcome any feedback and suggestions from our patron in order to serve them better. Our efforts have made us the prominent choice of diverse industries and companies.<br />