Prilocaine

Basic information:

Product Name: Prilocaine 

Synonyms: 2-(propylamino)-o-propionotoluidid;2-(Propylamino)-o-propionotoluidide;2-Methyl-alpha-propylaminopropionanilide;alpha-n-Propyl-amino-2-methylpropionanilide;alpha-n-propylamino-2-methylpropionanilide;Astra 1512;Astra 1515;astra1512 

CAS: 721-50-6 

MF: C13H20N2O 

MW: 220.31 

EINECS: 211-957-0 

Product Categories: Active Pharmaceutical Ingredients;Inhibitors 

Mol File: 721-50-6.mol 

Chemical Properties:

It is a kind of needle-like crystals with the melting point being 37-38 ℃ and the boiling point being 159-162 ℃ (0.133kPa), and refractive index (nD20) being 1.5299. Its hydrochloride ([1786-81-8]) is a white crystalline powder. The Melting point is 167-168 ℃. It is soluble in water and ethanol, slightly soluble in chloroform. It has sour taste and bitter taste and is odorless. 

Application:

Application It is a kind of local anesthetic drug. The product has better efficacy than procaine and the local anesthesia intensity and speed being similar as lidocaine but with longer duration time and less toxicity as well as smaller accumulation effect. It is suitable for epidural anesthesia, conduction anesthesia and infiltration anesthesia.  

Usage And Synthesis:

Prilocaine belongs to amide local anesthetic drug with its anesthesia intensity and speed being similar as lidocaine but with a longer duration period and weaker effect on vasodilation. It has a lower toxicity than lidocaine. It is clinically for local anesthesia, especially suitable for treating patients who are not allowed to use adrenaline. 

[Pharmacological] its 3% solution has a similar local anesthesia efficacy as the anesthesia drug of 2% lidocaine together with adrenaline. It has a slow onset time which lasts about 6 ~ 7min and the duration time of about 1.5 ~ 2h. It has a strong penetration capability through mucous membranes. Adrenaline has a slightly prolonged duration of action. PPB is 55% and T1/2 of about 1.5h. It is subject to liver metabolism with its metabolites nitroso toluidine being able to oxidize hemoglobin to form methemoglobin. It can be transported to the fetus through the placenta. 

[Adverse reactions] once the usage amount exceeds 600mg, methaemoglobinaemia can occur with cyanosis, tachycardia, headache, dizziness and weakness occurring. 

[Note] patients of anemia, congenital or acquired methaemoglobinaemia, respiratory failure or heart failure and hypoxic patients should be disabled. It is forbidden for applied to obstetric anesthesia. 

Usage and dosage:

infiltration anesthesia: 0.5% to 1% solution with the duration of action of 1 to 1.5 hours.

Nerve blocking anesthesia: use 1% to 2% solution with the duration of action being 2-3 hours.

Epidural anesthesia: use10 to 30 mL of 1.5% ~ 1% solution with the duration of action of 2.5 to 3.5 hours. Use a maximum dose of 600 mg.

Order Details:

Payment Methods:West Union,Moeny Gram and Bank Transfer

Delivery Ways:EMS,HKEMS,TNT,DHL,FedEX,UPS etc

Shipment Time:Within 8 hours after confirmation of your payment

Other Service:Safe shipment,high purity and best price for you

Featured Service:

Price:reasonable and favorable

Package:discreet and disguised.Detailed things can be discussed via email

Shipment methods:we can take different shipment ways for different countries

Other Service:parcel picture,tracking number and tracking website can be offered after shipment

Customs Rate:99.5% successful rate.if seized,our company will offer you re-shipment policy

Safe and discreet package

1).All products will have been strictly Quality Checked in house before packing. 2).All products will be well packed before shipping. 3)Parcel can be sent out in 24 hours after payment. Tracking number available 4)Secure and discreet shipment. Various transportation methods for your choice. 5)Customs pass rate ≥99% 6) We have our own agent/remailer/distributor who can help us ship our products very fast and safe, and we have stock in there for transferring.

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