Albendazole

Quick Details:

Description

Albendazole, marketed as Albenza among others, is a benzimidazolemedication used for the treatment of a variety of parasitic worminfestations. It is a broad-spectrum anthelmintic, effective againstroundworms, tapeworms, and flukes.

Albendazole is used for a wide range of diseases caused by parasitic worms including: giardiasis, trichuriasis, filariasis, neurocysticercosis,hydatid disease, enterobiasis, and ascariasis, among others.

Potentially serious side effects include bone marrow suppression which usually improves on stopping the medication. Liver inflammation has been reported and those

with prior liver problems are at greater risk.Common side effects include: nausea, abdominal pains,

and headaches. It ispregnancy category C in the United States and category D in Australia, meaning it may cause harm if taken by a pregnant

women.

Albendazole was first discovered at the SmithKlineAnimal HealthLaboratories in 1972. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications

needed in a basic health system. It is marketed in the U.S. by Amedra Pharmaceuticals, and by GlaxoSmithKline in

international markets.

Medical Use

It is effective first-line of treatment against:

· Flatworms

· Flukes/trematodes

· Fasciolosis

· Tapeworm/cestodes

· Cysticercosis

· Echinococcosis

· Nematodes

· Enterobiasis (pinworm infection)

· Trichuriasis (whipworm infection)

· Toxocariasis

· Ascariasis

· Hookworm

· Cutaneous larva migrans (caused by Ancylostoma)

· Filariasis

· Myiasis

Other uses

In Africa, albendazole is being used to treat lymphatic filariasis as part of efforts to stop transmission of the disease. In sub-Saharan Africa, albendazole is used in conjunction with ivermectin, and elsewhere in the world, the medicine is used in combination with diethylcarbamazine.

In Brazil and other countries, it is used against giardiasis.

Side Effects

Albendazole may cause abdominal pain, dizziness, headache, fever, nausea, vomiting, or temporary

hair loss.

In rare cases, it may cause persistent sore throat, severe headache, seizures, vision problems,

yellowing eyes or skin, dark urine, stomach pain, easy bruising, mental/mood changes, very stiff neck, or changes in amount of urine. Elevation of liver enzymes during treatment is a common side effect,

but in rare cases, acute liver failure has been reported. Allergic reactions are also possible.

Rarely, albendazole has been reported to cause marrow suppression, agranulocytosis, or aplastic anemia, which may be permanent..The risk of developing this side effect seems to be increased in patients with liver disease, including echinococcal cysts. Because of this dangerous side effect, it is

important to regularly monitor complete blood counts.

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