Name: Tadalafil

Quick Details:

Description

_{Tadalafil is PDE5 inhibitor marketed in pill form for treating erectile dysfunction (ED) under the name Cialis, and under the name Adcirca for the treatment of pulmonary arterial hypertension.}

_{In October 2011 the U.S. Food and Drug Administration (FDA) approved Cialis for treating the signs and symptoms of benign prostatic hyperplasia (BPH) as well as a combination of BPH and erectile dysfunction (ED) when the conditions coincide.}

_{It initially was developed by the biotechnology company}

_{ICOS, and then again developed and marketed world-wide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Cialistablets, in 2.5 mg, 5 mg, 10 mg, and 20 mg doses, are yellow,}

_{film-coated, and almond-shaped. The approved dose for pulmonary arterial hypertension is 40 mg}

_{(two 20-mg tablets) once daily.}

_{On November 21, 2003 the FDA approved tadalafil (as Cialis) for sale in the United States as the}

_{third ED prescription drug pill (after sildenafil citrate (Viagra) and vardenafil Hydrochloride (Levitra)). Like sildenafil and vardenafil, tadalafil is recommended as an 'as needed' medication.}

_{Cialis is the only one of the three that is also offered as a once-daily medication.}

_{Moreover, tadalafil was approved in May 2009 in the United States for the treatment of pulmonary}

_{arterial hypertension and is under regulatory review in other regions for this condition. In late}

_{November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary}

_{arterial hypertension in the United States to United Therapeutics for an upfront payment of $150}

_million.

Before using Tadalafil

You should not take tadalafil if you are allergic to it, or:

★if you take other medicines to treat pulmonary arterial hypertension, such as riociguat (Adempas).

Do not take tadalafil if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin,

isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs

such as amyl nitrate or nitrite ("poppers"). Taking tadalafil with a nitrate medicine can cause a sudden

and serious decrease in blood pressure.

To make sure tadalafil is safe for you, tell your doctor if you have any of these other conditions:

★heart disease or heart rhythm problems, coronary artery disease;

★a recent heart attack (within the past 90 days);

★a recent history (in the past 6 months) of a stroke, or congestive heart failure;

★angina (chest pain), high or low blood pressure;

★liver or kidney disease (or if you are on dialysis);

★a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;

★a bleeding disorder such as hemophilia;

★a stomach ulcer;

★retinitis pigmentosa (an inherited condition of the eye);

★a physical deformity of the penis (such as Peyronie's disease); or

★if you have been told you should not have sexual intercourse for health reasons.

Tadalafil can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has

occurred in a small number of people taking tadalafil, most of whom also had heart disease, diabetes,

high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old.

This medicine is not expectedto harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

It is not known whether tadalafil passes into breast milk or if it could harm a nursing baby. Tell your

doctor if you are breast-feeding a baby.

Uses

Tadalafil is used to treat male sexual function problems (impotence or erectile dysfunction-ED). In combination with sexual stimulation, tadalafil works by increasingblood flow to the penis to help a man get and keep an erection.

Tadalafil is also used to treat the symptoms of an enlarged prostate (benign prostatic hyperplasia-BPH). It helps to relieve symptoms of BPH such as difficulty in beginning the flow of urine, weak stream, and the need to urinate frequently or

urgently (including during the middle of the night). Tadalafil is thought to work by relaxing the smooth

muscle in the prostate and bladder.

This drug does not protect against sexually transmitted diseases (such as HIV,hepatitis B, gonorrhea, syphilis). Practice "safe sex" such as using latex condoms. Consult your doctor or pharmacist for more details.

OTHER USES:

This section contains uses of this drug that are not listed in the approved professional labeling for

the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so

prescribed by your health care professional.

Tadalafil is also available in another brand for treating high blood pressure in the lungs(pulmonary hypertension).

Side effects

Get emergency medical help if you have any of these signs of an allergic reaction to tadalafil:

hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using tadalafil and get emergency medical help if you have:

★erection is painful or lasts longer than 4 hours (prolonged erection can damage the penis);

★vision changes or sudden vision loss; or

★heart attack symptoms - chest pain or pressure, pain spreading to your jaw or shoulder,

nausea, sweating.

Also call your doctor right away if you have:

★ringing in your ears, or sudden hearing loss;

★irregular heartbeat;

★swelling in your hands, ankles, or feet;

★shortness of breath;

★seizure (convulsions); or

★a light-headed feeling, like you might pass out.

Common tadalafil side effects may include;

★headache;

★sinus pain, sore throat; or

★muscle pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice

about side effects.

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