spirodiclofen (738)

Acaricide

NOMENCLATURE

Common name spirodiclofen (BSI, pa ISO)

IUPAC name 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutyrate 

Chemical Abstracts name 3-(2,4-dichlorophenyl)-2-oxo-1-oxaspiro[4.5]dec-3-en-4-yl 2,2-dimethylbutanoate 

CAS RN [148477-71-8]  Development codes BAJ2740 

PHYSICAL CHEMISTRY

Mol. wt. 411.3  M.f. C21H24Cl2O4  Form White powder.  V.p. 3 ´ 10-4 mPa (20 °C)  KOW logP = 5.8 (pH 4, 20 °C)  Henry 2.5 ´ 10-3 Pa m3 mol-1 (calc.)  Solubility In water 50 mg/l (pH 4, 20 °C). 

APPLICATIONS

Mode of action Interferes with mite development.  Uses Under development for control of mite pests such as Panonychus spp., Phyllocoptruta spp., Brevipalpus spp., and Aculus and Tetranychus species, at 50-200 g/1000 l. For use in citrus, pome fruit, stone fruit, grapes and nuts. Formulation types SC; WG.  Selected products: 'Envidor' (Bayer CropScience)

MAMMALIAN TOXICOLOGY

Oral Acute oral LD50 for male and female rats >2500 mg/kg.  Skin and eye Acute percutaneous LD50 for male and female rats >2000 mg/kg. Non-irritating to skin and eyes (rabbits). Not a skin sensitiser (SC formulation, guinea pigs).  Inhalation (4 h) for rats >5000 mg/m3.  NOEL NOAEL (12 mo) for dogs 50 ppm.  Other No teratogenic potential (rats and rabbits); 2-generation rat study revealed no evidence of a primary reprotoxic potential; no evidence of genotoxic or mutagenic potential. 

ECOTOXICOLOGY

Birds Acute oral LD50 >2000 mg/kg.  Fish LC50 (96 h) >68 mg a.i. (as 240SC)/l  Daphnia EC50 (48 h) >100 mg a.i. (as 240SC)/l  Bees LD50 (oral and contact) >300 mg/bee.  Worms LC50 for Eisenia foetida >1000 mg/kg dry soil.  Other beneficial spp. Non-toxic to ladybirds (Coccinella septempunctata) at 300 g/ha. Slightly harmful to predatory mites under field conditions (240SC; IOBC scale). No negative effect on microbial mineralisation. 

ENVIRONMENTAL FATE

Soil/Environment DT50 in soil 0.5-5.5 d. No leaching problem (lysimeter study).  

As one of the leading producer and supplier in China, AgroBase has been engaged in Agrochemical business Since 2012, we produce several pesticides a.i. and most of the formulations. We have a  professional team, all of our staff graduated from Agricultural university with Master or Doctor degree, whom has been in the market of agrochemicals for many years with rich experience in the registration of Agrochemicals and Marketting.