Paromomycin Sulfate(API)

      CAS No.: 1263-89-4
Specifications
Mainly used in intestinal infection such as bacterial dysentety,amebic dysentery
and enteritis etc.
 Antibiotics. Mainly used in intestinal infection such as bacterial
dysentety,amebic dysentery and enteritis etc.Properties white or pale yellow
tablet, or sugar coated.Identify the powder to remove the goods amount (such as
sugar-coated tablet, should remove sugar), water produced in each 1mlContains
about 20mg of paromomycin solution, and shake to dissolve paromomycin sulfate,
filtration, the filtrate obtained according to paromomycin sulfateIdentification
of under (2), (3) test, which was the same result.Check addition to
disintegration (suppression film) should collapse within 30 minutes, the tablets
should be consistent under the various relevantProvisionContent goods from the
10, said precision set, research and fine, precise weighed amount (about the
equivalent of paromomycin0.25g); such as sugar-coated tablet, take 4 tablets,
all study details. Add sterile water, and shake to dissolve paromomycin sulfate,
andDiluted to 1ml in each of about 1,000 units with suspension, shake, standing,
precision to measure the upper liquid amount, according to sulfuric acid
BaronDetermined under ADM.Category with paromomycin sulfate.Specification (1)
0.1g (10 million units) (2) 0.25g (25 million units)Storage sunscreen, sealed
and stored in a dry place.Pharmacology and Toxicology1. Pharmacological product
is aminoglycoside antibiotics. The antibacterial spectrum of paromomycin and
neomycin and kanamycin basically the same. Against Gram-positive and-negative
bacteria was inhibited by Shigella and Staphylococcus aureus on the role of more
significant, and no effect on Pseudomonas aeruginosa and anaerobic bacteria.
Strong inhibitory effect on the amoeba protozoa on Leishmania, Cryptosporidium,
filarial and other effects are also good.2. Toxicity of paromomycin in the ear,
kidney toxicity, it is not generally suitable for general
application.PharmacokineticsThis product is very little absorption after oral
administration. Most of the drugs to prototype with feces.Indications1. Mainly
used for the treatment of intestinal amoebiasis, intestinal amoebiasis on
invalid.2. Can be used for the treatment of intestinal cryptosporidiosis.3. Can
also be used before surgery to prepare the colon and liver coma.Usage
consumptionOral.1. Adult intestinal amoebiasis a 0.5g, 3 times a day for 7 days.
Children's day 30mg/kg, at times taking 3.2. Cryptosporidiosis in adults a 0.5 ~
0.75g, 3 times a day.3. Preparation before colon surgery adult patients with
hepatic coma a 1g, 3 times a day.Adverse reactionsOrally can cause loss of
appetite, nausea, vomiting, diarrhea, malabsorption syndrome can cause even.
Double infection can cause long-term oral administration.ContraindicationsOn
paromomycin and other aminoglycosides in patients allergic to disable.Notes1. Of
a cross-allergy, such as aminoglycoside antibiotics streptomycin, gentamicin or
amikacin in patients with allergic may also be allergic to this product.2. In
the drug over Cheng Zhongyi regular urine and kidney function test, to prevent
renal toxicity and hearing examinations or hearing electroretinogram
determination.3. The following conditions should be careful using this product:
water loss, 8 cranial nerve damage, myasthenia gravis, Parkinson's disease,
renal dysfunction and patients with ulcerative colitis.4. Long-term oral
administration of the goods, chronic intestinal infections, particularly
associated with renal dysfunction or with the services of other ototoxic or
nephrotoxic drugs, in particular, there should be pay attention to symptoms of
renal toxicity or ototoxicity possible.Pregnant and lactating women drugAlthough
very few of the products of oral absorption, but pregnant women should be used
with caution. Breastfeeding women in the breast-feeding should be suspended
during the service using this product.Pediatric UseThere is currently a lack of
premature and newborn children should use this product safety information, it
should not be applied in premature and newborn child. Medication in elderly
patientsElderly patients should carefully using this product.Drug
InteractionsThis product is not with the other renal toxicity or ototoxic drugs
combined.Furen Pharmaceutical Group is a comprehensive group, leading in
pharmaceutical industry. Our group has drug R&D, manufacture, marketing,
investment and management departments. Furen Medicines Group consists of
subsidiary companies as following:

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